Here it is, making the Official build of Thunderbird portable. In case you didn't already notice the post about making Firefox portable with the Official build, you may want to take a peek. Not that much of a difference in this post. Same song and dance, different app.
Thunderbird -profile "[Profile path]" -turbo[Profile path] can be anything, relative, absolute, as long as you don't end it with a trailing back slash.
"E:\Thunderbirddata\Profile\"Fails with a program crash.
With this you won't have to invoke
-CreateProfileto make a new profile, Thunderbird does that for you in the specified directory, and -turbo makes Thunderbird load faster.
I used the information from my post concerning Firefox, which based of the information supplied here.